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Erythropoietin Erythropoietin, also known as hematopoietin or hemopoietin, is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow. Exogenous erythropoietin, recombinant human erythropoietin (rhEPO) is produced by recombinant DNA technology in cell culture and are collectively called erythropoiesis-stimulating agents (ESAs). Wiki
UniProt: P01588
Enbrel Etanercept (trade name Enbrel) is a a fusion protein produced by recombinant DNA. It is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor (TNF, a soluble inflammatory cytokine) by acting as a TNF inhibitor. It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile rheumatoid arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. Wiki
About Enbrel®
Fetuin Fetuins are blood proteins that are made in the liver and secreted into the bloodstream. They belong to a large group of binding proteins mediating the transport and availability of a wide variety of cargo substances in the bloodstream. The best known representative of these carrier proteins is serum albumin, the most abundant protein in the blood plasma of adult animals. Wiki
UniProt: P02765
Herceptin Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer. Specifically it is used for breast cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication Wiki
About Herceptin
High mannose High-mannose is, in essence, just two N-acetylglucosamines with many mannose residues, often almost as many as are seen in the precursor oligosaccharides before it is attached to the protein. Profiling
Effect on IgG
Behavior in Breast Cancer
Human IgG Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in the circulation. IgG molecules are created and released by plasma B cells. Each IgG has two antigen binding sites. Wiki
Subclasses Measurements
PDB: 5JII 5W38  5W5M
Infliximab Infliximab (trade names Remicade among others) is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases. Infliximab was approved by the U.S. Food and Drug Administration (FDA) for the treatment of Crohn's disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis Wiki
About Remicade®
Invertase nvertase is an enzyme that catalyzes the hydrolysis (breakdown) of sucrose (table sugar). Alternative names for invertase include EC, saccharase, glucosucrase, beta-h-fructosidase, beta-fructosidase, invertin, sucrase, maxinvert L 1000, fructosylinvertase, alkaline invertase, acid invertase, and the systematic name: beta-fructofuranosidase. Wiki
Enzyme Data
Mouse IgG There are five antibody isotypes (IgA, IgD, IgE, IgG, and IgM) from mice. One of the important methods for generating humanized antibodies is through the immunization of transgenic mice with part of human immunoglobulin genomic sequence Compare with human IgG
Compare isoforms
NIST Recently, NIST released a monoclonal antibody standard reference material (NIST RM 8671) to be used as a common reference material for biopharmaceutical labs. It also provides a representative test molecule for development of novel technology for therapeutic protein characterization. About NIST